Hydrochloric Acid → 2-(4-Aminophenoxy)acetic acid hydrochloride

HRID 501830

Reaktionsgleichung

Reaktionsgleichung von HRID 501830
C([O:3][C:4](=[O:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][CH:8]=1)C.[ClH:18]>>[ClH:18].[NH2:13][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][C:4]([OH:17])=[O:3])=[CH:12][CH:11]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 309738Ethyl 2-(4-acetamidophenoxy)acetate

Produkt 1

HCID 668114882-(4-Aminophenoxy)acetic acid hydrochlorideAusbeute 77,6 %

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

(4-Acetylamino-phenoxy)-acetic acid ethyl ester 1 (375 grams, 1.582 mmol), in concentrated Hydrochloric acid (9.36 liters) was refluxed for 12 Hours. Excess concentrated Hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 2(250 g, 77.6%) as a wheat colored powder.

Aufarbeitung

  1. distillationExcess concentrated Hydrochloric acid was distilled off in vacuum
  2. filtrationfiltered hot
  3. filtrationfiltered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-88965aaa5e764a9a987fed00cee01d87
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772352B2

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