Hydrochloric Acid → HCID 66811347, Verbindung

HRID 501839

Reaktionsgleichung

Reaktionsgleichung von HRID 501839
C[O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16]C(=O)C)=[CH:12][CH:11]=1.[ClH:21]>>[ClH:21].[NH2:16][C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:20])=[O:2])=[CH:15][CH:14]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 497644916-(4-Acetylaminophenoxy)-hexanoic acid methyl ester

Produkt 1

HCID 66811347HCID 66811347, VerbindungAusbeute 55,6 %

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

6-(4-acetylaminophenoxy)-hexanoic acid methyl ester 15 (290 g, 1.04 mol), in conc. HCl (7.12 L) was refluxed for 48 hours. Excess conc. HCl was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 16 (150 g, 55.6%) as a brown powder with an m.p between 155-160° C.

Aufarbeitung

  1. distillationExcess conc. HCl was distilled off in vacuum
  2. filtrationfiltered hot
  3. filtrationfiltered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d62a41bbcbce4fa7b93f72201f0aa43d
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772352B2

Verknüpfte Notizen

Wird geladen…