6-(4-Nitrophenoxy)-hexanoic acid methyl ester → 6-(4-Nitrophenoxy)hexanoic acid

HRID 501852

Reaktionsgleichung

Reaktionsgleichung von HRID 501852
C[O:2][C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1>Cl>[N+:16]([C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:19])=[O:2])=[CH:15][CH:14]=1)([O-:18])=[O:17]

Komponenten

3

Edukt 1

HCID 146502956-(4-Nitrophenoxy)-hexanoic acid methyl ester

Produkt 1

HCID 223889056-(4-Nitrophenoxy)hexanoic acidAusbeute 80,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

6-(4-nitrophenoxy)-hexanoic acid methyl ester 21 (125 g, 468.16 mmol) was refluxed in conc. HCl (1250 ml) for 16 hours. The reaction mixture was cooled to room temp., filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 35 (95 g, 80.2%) as a white powder with an m.p. between 104-107° C.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled to room temp.
  2. filtrationfiltered
  3. customdried
  4. customrecrystallised from a mixture of ethyl acetate:hexane (1:6)

Quellen und Nachweise

ORD-Eintrag
ord-d1fe644fb5cc4660bc8da73d040dcbd9
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772352B2

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