Quinoline-6-carbonyl chloride → 4-methyl-N-(3-morpholinophenyl)-3-(6-quinolylcarbonylamino)benzamide

HRID 502050

Reaktionsgleichung

Reaktionsgleichung von HRID 502050
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11](Cl)=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[NH2:14][C:15]1[CH:16]=[C:17]([CH:33]=[CH:34][C:35]=1[CH3:36])[C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)[CH:22]=1)=[O:19]>>[CH3:36][C:35]1[CH:34]=[CH:33][C:17]([C:18]([NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[CH:22]=2)=[O:19])=[CH:16][C:15]=1[NH:14][C:11]([C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:1]=[CH:2][CH:3]=[CH:4]2)=[O:12]

Komponenten

3

Edukt 2

HCID 12391963Quinoline-6-carbonyl chlorideHCID 226361453-amino-4-methyl-N-(3-morpholinophenyl)benzamide

Produkt 1

HCID 226361594-methyl-N-(3-morpholinophenyl)-3-(6-quinolylcarbonylamino)benzamide

Versuchsvorschrift

Using an analogous procedure to that described in Example 1, 6-quinolylcarbonyl chloride was reacted with 3-amino-4-methyl-N-(3-morpholinophenyl)benzamide to give the title compound; NMR Spectrum: (DMSOd6) 2.35 (s, 3H), 3.0-3.1 (m, 4H), 3.65-3.75 (m, 4H), 6.65-6.7 (m, 1H), 7.17 (t, 1H), 7.3-7.35 (m, 1H), 7.38-7.48 (m, 2H), 7.6-7.7 (m, 1H), 7.8-7.85 (m, 1H), 8.0 (s, 1H), 8.1-8.15 (m, 1H), 8.3-8.35 (m, 1H), 8.5-8.55 (m, 1H), 8.7 (s, 1H), 8.98-9.02 (m, 1H), 10.0-10.1 (br s, 1H), 10.25-10.35 (br s, 1H); Mass Spectrum: M+H+ 467.

Quellen und Nachweise

ORD-Eintrag
ord-4578dd0d61204743944b65248f334b4d
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772432B2

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