Acetyl chloride → 5-Acetylamino-N-[1-(4-chloro-3-ethoxy-benzyl)piperidin-4-yl]-nicotinamide
Reaktionsgleichung
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:27]=1)[C:7]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([O:24][CH2:25][CH3:26])[CH:18]=2)[CH2:12][CH2:11]1)=[O:8].[C:28](Cl)(=[O:30])[CH3:29]>>[C:28]([NH:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:27]=1)[C:7]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([O:24][CH2:25][CH3:26])[CH:18]=2)[CH2:12][CH2:11]1)=[O:8])(=[O:30])[CH3:29]Komponenten
3
Versuchsvorschrift
The title compound (12 mg, 26%) was prepared analogously to example 7 by coupling of 5-amino-N-[1-(4-chloro-3-ethoxy-benzyl)piperidin-4-yl]-nicotinamide with acetyl chloride. MS: 431.4 (MH+).
Quellen und Nachweise
- ORD-Eintrag
- ord-b69736d535f345fc81120b0d8e3301c1
- Quelldatensatz
- uspto-grants-2010_08
- DOI