Trifluoroacetic acid → Trifluoroacetate

HRID 502672Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 502672
C(OC(=O)[NH:7][CH2:8][CH:9]1[CH2:13][CH2:12][CH2:11][S:10]1)(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>C(Cl)Cl>[S:10]1[CH2:11][CH2:12][CH2:13][CH:9]1[CH2:8][NH2:7].[F:15][C:16]([F:21])([F:20])[C:17]([O-:19])=[O:18]

Komponenten

5

Edukt 2

HCID 6422Trifluoroacetic acid2×HCID 68460638HCID 68460638, Verbindung

Produkt 2

HCID 84468TrifluoroacetateAusbeute 83 %HCID 15629560Tetrahydro-2-thiophenemethanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of 2-[(N-tbutoxycarbonlylamino)methyl]-tetrahydrothiophene 222 (500 mg, 2.3 mmol) in DCM (25 mL) was treated with trifluoroacetic acid (10 mL). The mixture was stirred at rt for 1 h before the DCM and excess TFA were removed under reduced pressure. The oily residue was triturated with diethyl ether to afford 223 as its trifluoroacetate salt (440 mg, 1.9 mmol, 83%) as an off-white solid, which was used without further purification.

Aufarbeitung

  1. customwere removed under reduced pressure
  2. customThe oily residue was triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-74f7f6cb35b34a97b55b6f19c66b4494
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776867B2

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