Ethyl Acetate → 5-Bromo-2-chloro-4-(2-ethoxyphenoxy)pyrimidine

HRID 502789

Reaktionsgleichung

Reaktionsgleichung von HRID 502789
[H-].[Na+].[O:3]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[OH:12])[CH2:4][CH3:5].[Br:13][C:14]1[C:15](Cl)=[N:16][C:17]([Cl:20])=[N:18][CH:19]=1.CCOC(C)=O>CN(C=O)C.CC#N>[Br:13][C:14]1[C:15]([O:12][C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:3][CH2:4][CH3:5])=[N:16][C:17]([Cl:20])=[N:18][CH:19]=1

Komponenten

7

Edukt 4

HCID 8857Ethyl AcetateHCID 24758Sodium hydrideHCID 667552-EthoxyphenolHCID 2899735-Bromo-2,4-dichloropyrimidine

Produkt 1

HCID 790765415-Bromo-2-chloro-4-(2-ethoxyphenoxy)pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 6342AcetonitrileLösungsmittel2×

Versuchsvorschrift

To a suspension of NaH (0.42 g 60% in mineral oil, 10.5 mmol) in DMF (8.0 mL) was slowly added 2-ethoxylphenol (1.34 g, 9.7 mmol) in MeCN (4.0 mL) at 0° C. under N2. After the addition, the reaction mixture was allowed to warm up to room temperature for 0.5 hour. 5-bromo-2,4-dichloropyrimidine (2.0 g, 8.8 mmol) in MeCN (16.0 mL) was slowly added and then the resulting reaction mixture was stirred at room temperature for 24 hour. EtOAc (120 mL) was added and washed with NaOH (30 mL, 0.5N) and brine (25×2 mL). The organic layer was dried with MgSO4, and concentrated under reduced pressure. The residue was purified by silica gel chromatography (10% to 30% EtOAc in Hexanes, gradient elution) to provide the 5-bromo-2-chloro-4-(2-ethoxyphenoxy)pyrimidine. MS m/z=330 [M+1]+. Calc'd for: C12H10BrClN2O2: 329

Aufarbeitung

  1. customat 0° C.
  2. additionAfter the addition
  3. customthe resulting reaction mixture
  4. washwashed with NaOH (30 mL, 0.5N) and brine (25×2 mL)
  5. dry with materialThe organic layer was dried with MgSO4
  6. concentrationconcentrated under reduced pressure
  7. customThe residue was purified by silica gel chromatography (10% to 30% EtOAc in Hexanes, gradient elution)

Quellen und Nachweise

ORD-Eintrag
ord-e1d285d73a0646e98c67c67f757d3ab4
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776869B2

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