HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,6-Dioxaspiro[2.5]octane → tert-butyl({1-[(4-hydroxytetrahydro-2H-pyran-4-yl)methyl]piperidin-4-yl}methyl)carbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,6-Dioxaspiro[2.5]octane | HCID 160439 | — |
| Edukt | Tert-butyl (piperidin-4-ylmethyl)carbamate | HCID 723429 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | tert-butyl({1-[(4-hydroxytetrahydro-2H-pyran-4-yl)methyl]piperidin-4-yl}methyl)carbamate | HCID 59255059 | — |
Reaktionsschritte
To a stirred solution of tert-butyl(piperidin-4-ylmethyl)carbamate (22.3 g, 104 mmol) in methanol was added 1,6-dioxaspiro[2.5]octane (14.2 g, 124 mmol, Satyamurthy, Nagichettiar et al., Phosphorus Sulfur, 1984, 19, 113) at ambient temperature.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07776885B2 |
| Quelldatensatz | uspto-grants-2010_08 |
| ORD ID | ord-4915662e86cd4417b09f827755efa109 |
| Quellennotiz | uspto-grants-2010_08 |