Toluene → Methyl 3-[(cyclopropylamino)carbonyl]benzoate

HRID 502964Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 502964
[C:1]1([CH3:7])C=CC=C[CH:2]=1.[CH3:8][O:9][C:10]([C:12]1[CH:13]=[C:14]([C:18]([OH:20])=O)[CH:15]=[CH:16][CH:17]=1)=[O:11].S(Cl)(Cl)=O.C[N:26](C=O)C>C(Cl)(Cl)Cl>[CH:1]1([NH:26][C:18]([C:14]2[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=2)[C:10]([O:9][CH3:8])=[O:11])=[O:20])[CH2:2][CH2:7]1

Komponenten

6

Edukt 4

HCID 1140TolueneHCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 6018803-(Methoxycarbonyl)benzoic acid

Produkt 1

HCID 47231565Methyl 3-[(cyclopropylamino)carbonyl]benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Toluene solution of 3-(Methoxycarbonyl)benzenecarboxylic acid, thionyl chloride and DMF (a catalytic amount) were heated under stirring. The reaction solution was dissolved in chloroform after evaporation under reduced pressure. After cyclopropylamine and triethylamine were added thereto and the whole was stirred at room temperature to obtain methyl 3-[(cyclopropylamino)carbonyl]benzoate.

Aufarbeitung

  1. customafter evaporation under reduced pressure
  2. additionAfter cyclopropylamine and triethylamine were added
  3. stirringthe whole was stirred at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-7970b8c847374f64b42bda5eaa1518c8
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776897B2

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