HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Carbonochloridic acid, octyl ester → methyl 3-[[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Carbonochloridic acid, octyl ester | HCID 81956 | — |
| Edukt | 1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)amide Hydrochloride | HCID 18412516 | — |
| Lösungsmittel | Dichloromethane methanol | HCID 21226129 | — |
| Produkt | methyl 3-[[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate | HCID 140409603 | 57% |
Reaktionsschritte
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)amide hydrochloride and n-octyl chloroformate. Yield: 57% of theory, C35H43N7O5 (641.8); Rf value: 0.60 (silica gel; dichloromethane/methanol=9:1); EKA mass spectrum: (M+H)+=642; (M+H+Na)++=332.8; (M+Na)+=664.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06710055B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-088fb6b1111a49b88947c088c5ebd0f9 |
| Quellennotiz | uspto-grants-2004_03 |