Trifluoroacetic acid → [3-(3-Fluorophenyl)-1H-5-indazolyl]methanamine

HRID 503134

Reaktionsgleichung

Reaktionsgleichung von HRID 503134
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8](C(OC(C)(C)C)=O)[N:7]=[C:6]2[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:25][C:21]1[CH:20]=[C:19]([C:6]2[C:5]3[C:9](=[CH:10][CH:11]=[C:3]([CH2:2][NH2:1])[CH:4]=3)[NH:8][N:7]=2)[CH:24]=[CH:23][CH:22]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 222606941h-Indazole-1-carboxylic acid,5-(aminomethyl)-3-(3-fluorophenyl)-,1,1-dimethylethyl ester

Produkt 1

HCID 22260728[3-(3-Fluorophenyl)-1H-5-indazolyl]methanamineAusbeute 88,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 300 mg of tert-butyl 5-(aminomethyl)-3-(3-fluorophenyl)-1H-1-indazolecarboxylate in 1 ml methylene chloride was added 2 ml of trifluoroacetic acid, and the mixture was stirred at room temperature for 6.5 hours. After removing the solvent by filtration, to the residue was added 20 ml of ethyl acetate. The mixture was sequentially washed with saturated aqueous sodium hydrogencarbonate solution (×2) and brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 188 mg of the title compound as yellow crystals.

Aufarbeitung

  1. customAfter removing the solvent
  2. filtrationby filtration
  3. additionto the residue was added 20 ml of ethyl acetate
  4. washThe mixture was sequentially washed with saturated aqueous sodium hydrogencarbonate solution (×2) and brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-144956c593204410bf9a8b80913c8a9b
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776890B2

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