HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pentyl chloroformate → methyl 3-[[1-methyl-2-[[4-(N-pentoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pentyl chloroformate | HCID 69489 | — |
| Edukt | 1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)amide Hydrochloride | HCID 18412516 | — |
| Lösungsmittel | Dichloromethane methanol | HCID 21226129 | — |
| Produkt | methyl 3-[[1-methyl-2-[[4-(N-pentoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate | HCID 140435598 | 66% |
Reaktionsschritte
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)amide hydrochloride and n-pentyl chloroformate. Yield: 66% of theory, C32H37N7O5 (599.7); Rf value: 0.58 (silica gel; dichloromethane/methanol=9:1); EKA mass spectrum: (M+H)+=600; (M+H+Na)++=311.7; (M+Na)+=622.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06710055B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-3b71b4ec4ce041e5bf3625fe6295c6ff |
| Quellennotiz | uspto-grants-2004_03 |