HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Carbonochloridic acid, octyl ester → ethyl 3-[[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-3-ylamino]propanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Carbonochloridic acid, octyl ester | HCID 81956 | — |
| Edukt | 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(3-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride | HCID 18412473 | — |
| Lösungsmittel | Dichloromethane ethanol | HCID 21584144 | — |
| Produkt | ethyl 3-[[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-3-ylamino]propanoate | HCID 140443503 | 35% |
Reaktionsschritte
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(3-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-octyl chloroformate. Yield: 35% of theory, C36H45N7O5 (655.8); Rf value: 0.28 (silica gel; dichloromethane/ethanol=19:1); EKA mass spectrum: (M+H)+=656; (M+2H)++=328.7.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06710055B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-889aebb0368e40aa9d1a5a9f0df5d1be |
| Quellennotiz | uspto-grants-2004_03 |