1,12-Bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane dihydroiodide → 1,12-Bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane diacetate

HRID 5033

Reaktionsgleichung

Reaktionsgleichung von HRID 5033
I.I.[NH2:3][C:4]1[N:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][N:24]=[C:23]2[NH2:28])[CH2:8][CH2:7][CH2:6][N:5]=1.[CH3:29][OH:30].[OH2:31]>>[C:29]([OH:31])(=[O:30])[CH3:4].[C:29]([OH:31])(=[O:30])[CH3:4].[NH2:3][C:4]1[N:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][N:24]=[C:23]2[NH2:28])[CH2:8][CH2:7][CH2:6][N:5]=1

Komponenten

3

Edukt 2

HCID 190888341,12-Bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane dihydroiodideHCID 22242641Methanol--water (1/1)

Produkt 1

HCID 678670541,12-Bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane diacetate

Versuchsvorschrift

30.0 g (0.048 mol) of 1,12-bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane dihydroiodide in 300 ml of methanol/water (1:1) were filtered through a column containing 250 g of ion exchanger (OH- form). The free guanidine base obtained after working up was dissolved in methanol and converted into the diacetate with excess glacial acetic acid.

Quellen und Nachweise

ORD-Eintrag
ord-62caf7e77d574b0eacf847ea9cbf3833
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05242948

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