Hydrochloric Acid → HCID 24861656, Verbindung

HRID 503656Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 503656
[OH:1][CH:2]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([OH:38])[CH:33]=1)[C:3]([NH:5][NH:6][C:7](=[O:31])[C:8]1[C:13]([O:14]CC2C=CC=CC=2)=[CH:12][C:11]([O:22]CC2C=CC=CC=2)=[CH:10][C:9]=1[Cl:30])=[O:4].Cl>C1COCC1>[OH:1][CH:2]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([OH:38])[CH:33]=1)[C:3]([NH:5][NH:6][C:7](=[O:31])[C:8]1[C:13]([OH:14])=[CH:12][C:11]([OH:22])=[CH:10][C:9]=1[Cl:30])=[O:4]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 57857230HCID 57857230, Verbindung

Produkt 1

HCID 24861656HCID 24861656, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

720 mg of N′-[2-hydroxy-2-(3-hydroxyphenyl)acetyl]-2-chloro-4,6-dibenzyloxybenzohydrazide in 20 ml of THF+0.2 ml of 32% HCl are hydrogenated with the calculated amount of H2 using 360 mg of PdoC. The hydrogenation solution is evaporated and chromatographed on silica gel. The uniform fractions are combined, evaporated and recrystallised from EtOAc. Yield 310 mg (65%) of “A15”, m.p. 230-231°.

Aufarbeitung

  1. customThe hydrogenation solution is evaporated
  2. customchromatographed on silica gel
  3. customevaporated
  4. customrecrystallised from EtOAc

Quellen und Nachweise

ORD-Eintrag
ord-e64e2c6f095647f6b5861e9b05bec565
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776920B2

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