Potassium Carbonate → 3-(N,N-diethylaminopropoxy)butyranilide

HRID 503667

Reaktionsgleichung

Reaktionsgleichung von HRID 503667
S([O-])(=O)(=O)C.[CH2:6]([N:8]([CH:11](O)[CH2:12][CH3:13])[CH2:9][CH3:10])[CH3:7].[C:15]([NH:20][C:21]1[CH:22]=[C:23](O)[CH:24]=[CH:25][CH:26]=1)(=[O:19])[CH2:16][CH2:17][CH3:18].C([O-])([O-])=[O:29].[K+].[K+]>CN(C=O)C>[CH2:6]([N:8]([CH2:11][CH2:12][CH2:13][O:29][CH:17]([CH3:18])[CH2:16][C:15]([NH:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:19])[CH2:9][CH3:10])[CH3:7]

Komponenten

6

Edukt 4

HCID 11430Potassium CarbonateHCID 30688Butyranilide, 3'-hydroxy-HCID 85257MethanesulfonateHCID 5256659Diethylamino-propanol

Produkt 1

HCID 684282403-(N,N-diethylaminopropoxy)butyranilideAusbeute 88,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The mesylate of N,N-diethylaminopropanol (6 mmol), prepared as described in Example 18 above, was mixed with 3-butyramidophenol (5.0 mmol), and K2CO3 (10 mmol) in anhydrous DMF (10 mL) and the reaction is performed following general procedure B. The crude product is purified using silica gel column chromatography 5% MeOH/DCM as eluent to yield 3-(N,N-diethylaminopropoxy)butyranilide (1.3 g).

Aufarbeitung

  1. customThe crude product is purified

Quellen und Nachweise

ORD-Eintrag
ord-b16b596d33f145d9bb5ca5ecfd40c02f
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776919B2

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