3-(Trifluoromethyl)-4-methylphenyl Isocyanate → 1-(5-Methyl-1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-3-(4-methyl-3-trifluoromethyl-phenyl)-urea

HRID 503836

Reaktionsgleichung

Reaktionsgleichung von HRID 503836
[CH3:1][C:2]1[CH:17]=[CH:16][C:5]2[N:6]([CH2:9][C:10]3[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=3)[CH:7]=[N:8][C:4]=2[C:3]=1[NH2:18].[N:19]([C:22]1[CH:27]=[CH:26][C:25]([CH3:28])=[C:24]([C:29]([F:32])([F:31])[F:30])[CH:23]=1)=[C:20]=[O:21]>ClCCl>[CH3:1][C:2]1[CH:17]=[CH:16][C:5]2[N:6]([CH2:9][C:10]3[CH:11]=[CH:12][N:13]=[CH:14][CH:15]=3)[CH:7]=[N:8][C:4]=2[C:3]=1[NH:18][C:20]([NH:19][C:22]1[CH:27]=[CH:26][C:25]([CH3:28])=[C:24]([C:29]([F:30])([F:32])[F:31])[CH:23]=1)=[O:21]

Komponenten

4

Edukt 2

HCID 34491703-(Trifluoromethyl)-4-methylphenyl IsocyanateHCID 594286405-Methyl-1-(pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine

Produkt 1

HCID 498059661-(5-Methyl-1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-3-(4-methyl-3-trifluoromethyl-phenyl)-urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Compound 2d (100 mg, 0.42 mmol) is weighed into a round bottom flask and dissolved in dichloromethane (3 mL). 4-Isocyanato-1-methyl-2-trifluoromethyl-benzene (85 mg, 0.42 mmol) is added as a solid and the homogeneous mixture is stirred for 4 h. The precipitate is collected via filtration and the solids are washed with ether and collected to yield compound 2h as a white amorphous solid.

Aufarbeitung

  1. filtrationThe precipitate is collected via filtration
  2. washthe solids are washed with ether
  3. customcollected

Quellen und Nachweise

ORD-Eintrag
ord-77bfb911d41e4557ad11ceb3958ff82c
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07777040B2

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