HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pentyl chloroformate → ethyl 3-[[2-[[2-methoxy-4-(N-pentoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pentyl chloroformate | HCID 69489 | — |
| Edukt | 1-methyl-2-[N-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride | HCID 18412588 | — |
| Lösungsmittel | Dichloromethane ethanol | HCID 21584144 | — |
| Produkt | ethyl 3-[[2-[[2-methoxy-4-(N-pentoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate | HCID 140435594 | 72% |
Reaktionsschritte
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-pentyl chloroformate. Yield: 72% of theory, C34H41N7O6 (643.7); Rf value: 0.49 (silica gel; dichloromethane/ethanol=9:1); EKA mass spectrum: (M+H)+=644; (M+H+Na)++=333.9.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06710055B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-fd224da8f040456d882ef373b4fd7d51 |
| Quellennotiz | uspto-grants-2004_03 |