Benzylamine → N-[(Trimethylsilyl)methyl]benzylamine

HRID 504390

Reaktionsgleichung

Reaktionsgleichung von HRID 504390
Cl[CH2:2][Si:3]([CH3:6])([CH3:5])[CH3:4].[CH2:7]([NH2:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[OH-].[Na+]>>[CH2:7]([NH:14][CH2:2][Si:3]([CH3:6])([CH3:5])[CH3:4])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

4

Edukt 3

HCID 7504BenzylamineHCID 14798Sodium HydroxideHCID 75361Silane, (chloromethyl)trimethyl-

Produkt 1

HCID 353458N-[(Trimethylsilyl)methyl]benzylamine

Reaktionsbedingungen

Temperatur
200 °C

Versuchsvorschrift

Into a round bottom 3-neck flask equipped with a nitrogen flow, a magnetic stirrer, and a friedrichs condenser was added (chloromethyl)trimethylsilane (0.100 mol). To the flask was added benzylamine (0.300 mol), with stirring, and the resulting solution heated at 200° C. for 2.5 hours. Sodium hydroxide aqueous solution (0.1N) was added in order to hydrolyze the white organic salt that had formed. The mixture was extracted with ether and the ether layer was dried over magnesium sulfate and concentrated under reduced pressure through a Vigreux column to give the product at b.p. 68-72° C./0.7-0.8 mm.

Aufarbeitung

  1. customInto a round bottom 3-neck flask equipped with a nitrogen flow, a magnetic stirrer, and a friedrichs condenser
  2. customhad formed
  3. extractionThe mixture was extracted with ether
  4. dry with materialthe ether layer was dried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure through a Vigreux column
  6. customto give the product at b.p. 68-72° C./0.7-0.8 mm

Quellen und Nachweise

ORD-Eintrag
ord-7ad37f2ee00d4b24a80da9b4ab46cdd9
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776874B2

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