Hydrochloric Acid → 4-bromo-1H-indazole

HRID 505024

Reaktionsgleichung

Reaktionsgleichung von HRID 505024
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][N:6]2C(=O)C.Cl>CO>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 454801851-Acetyl-4-bromo-1H-indazole

Produkt 1

HCID 223525484-bromo-1H-indazoleAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of the 1-(4-bromo-indazol-1-yl)-ethanone (3.09 g, 12.9 mmol) in MeOH (50 mL) was added 6N aqueous HCl (30 mL) and the mixture was stirred at room temperature for 7 h. The MeOH was evaporated and the mixture partitioned between EtOAc (2×50 mL) and water (50 mL). The combined organic layers were washed with brine (50 mL), separated and dried (MgSO4). The solvent was removed by evaporation under reduced pressure to give 4-bromo-1H-indazole (2.36 g, 93%).

Aufarbeitung

  1. customThe MeOH was evaporated
  2. customthe mixture partitioned between EtOAc (2×50 mL) and water (50 mL)
  3. washThe combined organic layers were washed with brine (50 mL)
  4. customseparated
  5. dry with materialdried (MgSO4)
  6. customThe solvent was removed by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a51f6ba0e1f547a0a7832e45ada72a19
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07781433B2

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