2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid → 3-{4-[2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoylamino]-imidazol-1-yl}-3-methyl-butyric acid methyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid	HCID 21112802	—
Edukt	3-Methyl-3-(4-nitro-imidazol-1-yl)-butyric acid methyl ester	HCID 67164961	—
Produkt	3-{4-[2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoylamino]-imidazol-1-yl}-3-methyl-butyric acid methyl ester	HCID 11684069	—

Reaktionsschritte

3-Methyl-3-(4-nitro-imidazol-1-yl)-butyric acid methyl ester was reduced and coupled with 2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid to afford the title compound; MS 463.5 m/z (M+1).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07781435B2
Quelldatensatz	uspto-grants-2010_08
ORD ID	ord-67f5fa477f18461a96c9b82137c7dcc4
Quellennotiz	uspto-grants-2010_08