2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid → 2-{4-[2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoylamino]-imidazol-1-yl}-2-methyl-propionic acid methyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid	HCID 21112802	—
Edukt	methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate	HCID 67164903	—
Produkt	2-{4-[2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoylamino]-imidazol-1-yl}-2-methyl-propionic acid methyl ester	HCID 11705041	—

Reaktionsschritte

2-Methyl-2-(4-nitro-imidazol-1-yl)-propionic acid methyl ester was reduced and coupled with 2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid to afford the title compound; MS 449.3 m/z (M+1).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07781435B2
Quelldatensatz	uspto-grants-2010_08
ORD ID	ord-f0a91a09417249f38e23402aa6407ade
Quellennotiz	uspto-grants-2010_08