2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid → (S)-2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid {1-[2-(2-ethoxy-ethylamino)-1,1-dimethyl-ethyl]-1H-imidazol-4-yl}-amide
Reaktionsgleichung
[CH2:1]([O:3][CH2:4][CH2:5][NH:6][CH2:7][C:8]([CH3:18])([N:10]1[CH:14]=[C:13]([N+:15]([O-])=O)[N:12]=[CH:11]1)[CH3:9])[CH3:2].[F:19][C:20]1[CH:21]=[C:22]2[C:27](=[C:28]([F:30])[CH:29]=1)[CH2:26][CH:25]([NH:31][CH:32]([CH2:36][CH2:37][CH3:38])[C:33](O)=[O:34])[CH2:24][CH2:23]2>>[CH2:1]([O:3][CH2:4][CH2:5][NH:6][CH2:7][C:8]([N:10]1[CH:14]=[C:13]([NH:15][C:33](=[O:34])[C@@H:32]([NH:31][CH:25]2[CH2:24][CH2:23][C:22]3[C:27](=[C:28]([F:30])[CH:29]=[C:20]([F:19])[CH:21]=3)[CH2:26]2)[CH2:36][CH2:37][CH3:38])[N:12]=[CH:11]1)([CH3:18])[CH3:9])[CH3:2]Komponenten
3
Versuchsvorschrift
(2-Ethoxy-ethyl)-[2-methyl-2-(4-nitro-imidazol-1-yl)-propyl]-amine was reduced and then coupled with 2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid (U.S. Ser. No. 11/078,898 filed Mar. 11, 2005) to afford the title compound: MS 492.6 m/z (M+1).