N-(6-Aminohexyl)-1-naphthalenesulfonamide → Naphthalene-1-sulfonic acid [6-(4-amino-quinazolin-2-ylamino)-hexyl]-amide

Beteiligte Stoffe

Reaktionsschritte

A solution of naphthalene-1-sulfonic acid (6-amino-hexyl)-amide (0.450 g) and 2-chloro-quinazolin-4-ylamine (see: U.S. Pat. No. 3,956,495) (0.264 g) in 20 ml of isopentylalcohol is heated up to 120° C. for 15 h. Concentration of the reaction mixture followed by chromatography on silica gel (B1) yields naphthalene-1-sulfonic acid [6-(4-amino-quinazolin-2-ylamino)-hexyl]-amide as a white powder, melting at 98-101° C. Rf(B1) 0.28, FAB-MS: (M+H)+=450. Analytical C26H29N5O2S+HCl+H2O+0.6 1,4 dioxane. m.p. 98-101° C.

Herkunft & Nachweise