Methanol → (R)-2-Hydroxy-1-morpholinopropan-1-one

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To (R)-methyl lactate (24.42 g, 0.23 mol) were added morphline (21.46 g, 0.25 mol) and sodium methoxide in methanol (14%, 9.04 g, 0.02 mol) and the mixture was stirred for 3 hours at 50° C. After removal of the solvent in vacuo, the residue was subjected to azeotropic distillation three times with toluene to give the subject compound (quant.).

Herkunft & Nachweise