HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(-)-2-Butanol → (+/-)-(3SR,3aRS)-((R)-sec-butyl) 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (-)-2-Butanol | HCID 84682 | — |
| Edukt | (+/-)(3SR,3aRS)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid | HCID 24983760 | — |
| Produkt | (+/-)-(3SR,3aRS)-((R)-sec-butyl) 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylate | HCID 68800247 | 68% |
Reaktionsschritte
The title compound was prepared from (±)-(3SR,3aRS)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid, Example 15 and (R)-butan-2-ol according to Method E (yellow solid, 155 mg, 0.326 mmol, 68% yield). ES-HRMS m/z calc. for C28H31ClN3O2 (M+H) 476.2099, found 476.2100.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07781428B2 |
| Quelldatensatz | uspto-grants-2010_08 |
| ORD ID | ord-1804d183a7df4d24968994cfede87a89 |
| Quellennotiz | uspto-grants-2010_08 |