Tetramethoxypropane → 2-(5-Bromopyridin-3-yl)pyrimidine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of the product of Step B (4.86 g, 20.5 mmol) and 1,1,3,3-tetramethoxypropane (6.59 mL, 40 mmol) in DMF (25 mL) was warmed to 90° C. under N2. After 18 h, the reaction mixture was allowed to cool to 25° C., concentrated in vacuo. Purification of the residue by flash chromatography (EtOAc) afforded the title compound (1.05 g, 22%) as a white solid. MS 237 (M+H)+

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