HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Amino-1-Boc-piperidine → 1,1-Dimethylethyl 4-[({[2-(ethyloxy)-2-oxoethyl]oxy}carbonyl)amino]piperidine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| Edukt | Ethyl [(phenoxycarbonyl)oxy]acetate | HCID 12094709 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 1,1-Dimethylethyl 4-[({[2-(ethyloxy)-2-oxoethyl]oxy}carbonyl)amino]piperidine-1-carboxylate | HCID 68465074 | — |
Reaktionsschritte
A suspension of 5.09 g (25.42 mmol) of 1,1-dimethylethyl 4-aminopiperidine-1-carboxylate and 13.45 g (59.99 mmol) of ethyl [(phenyloxycarbonyl)oxy]acetate (J. Med. Chem., 1999, 42, 277-90) in 300 ml of toluene is heated at reflux for 30 hours.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07781590B2 |
| Quelldatensatz | uspto-grants-2010_08 |
| ORD ID | ord-2370f5c8e8374cbea93b091642512d3f |
| Quellennotiz | uspto-grants-2010_08 |