Acetonitrile → 1-Naphthalenesulfonylaminoethylthioethylamine

Reaktionsgleichung

N[CH2:2][CH2:3][S:4][CH2:5][CH2:6][NH2:7].[C:8]1([S:18](Cl)(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1.C(#[N:24])C>>[C:8]1([S:18]([NH:24][CH:3]([S:4][CH2:5][CH2:6][NH2:7])[CH3:2])(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1

Komponenten

Edukt 3

HCID 6342Acetonitrile

HCID 665601-Naphthalenesulfonyl chloride

HCID 700962,2'-Thiobis(ethanamine)

Produkt 1

HCID 698871031-Naphthalenesulfonylaminoethylthioethylamine

Versuchsvorschrift

Under ice cooling, 5.29 g of aminoethylthioethylamine was added dropwise with 120 mL of acetonitrile solution in which 1.00 g of 1-naphthalenesulfonyl chloride was dissolved, and the mixture was stirred at room temperature for two days. The reaction mixture was evaporated under reduced pressure, and then the residue was added with 500 mL of water and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure to obtain 1.50 g of 1-naphthalenesulfonylaminoethylthioethylamine.