Cadaverine → N-(5-aminopentyl)naphthalene-1-sulfonamide

HRID 50611

Reaktionsgleichung

Reaktionsgleichung von HRID 50611
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[C:8]1([S:18](Cl)(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1>C(#N)C>[C:8]1([S:18]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7])(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 273CadaverineHCID 665601-Naphthalenesulfonyl chloride

Produkt 1

HCID 4303N-(5-aminopentyl)naphthalene-1-sulfonamideAusbeute 84,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Under ice cooling, 7.91 g of 1,5-diaminopentane was added dropwise with 240 mL of acetonitrile solution in which 1.75 g of 1-naphthalenesulfonyl chloride was dissolved, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was evaporated under reduced pressure, and the residue was added with 500 mL of water and extracted with dichloromethane. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain 1.90 g of 5-(1-naphthalenesulfonyl)aminopentylamine.

Aufarbeitung

  1. dissolutionwas dissolved
  2. customThe reaction mixture was evaporated under reduced pressure
  3. additionthe residue was added with 500 mL of water
  4. extractionextracted with dichloromethane
  5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e8b2e0abf9594c33858deb2304f39cd4
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713473B1

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