8-Methyl-8-azabicyclo[3.2.1]octan-3-amine → HCID 11674936, Verbindung

HRID 506226Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 506226
[NH2:1][CH:2]1[CH2:8][CH:7]2[N:9]([CH3:10])[CH:4]([CH2:5][CH2:6]2)[CH2:3]1.[C:11]1([C:17]2[O:18][C:19]3[C:20](=[C:22]([C:26](O)=[O:27])[CH:23]=[CH:24][CH:25]=3)[N:21]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH3:10][N:9]1[CH:7]2[CH2:6][CH2:5][CH:4]1[CH2:3][CH:2]([NH:1][C:26]([C:22]1[CH:23]=[CH:24][CH:25]=[C:19]3[O:18][C:17]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[N:21][C:20]=13)=[O:27])[CH2:8]2

Komponenten

3

Edukt 2

HCID 4083948-Methyl-8-azabicyclo[3.2.1]octan-3-amineHCID 108683692-Phenylbenzoxazole-4-carboxylic acid

Produkt 1

HCID 11674936HCID 11674936, VerbindungAusbeute 25 %

Versuchsvorschrift

N-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-phenylbenzoxazole-4-carboxamide was prepared from 3-amino-8-methyl-8-azabicyclo[3.2.1]octane and 2-phenylbenzoxazole-4-carboxylic acid using conditions similar to those described for Step C in Example 1. This compound was obtained in 25% yield as a white solid; mp 149-151° C.; 1H NMR (300 MHz, CDCl3) δ 9.55 (d, J=7.6 Hz, 1H), 8.29 (m, 2H), 8.22 (dd, 1H, J=7.8, 1.0 Hz, 1H), 7.72 (dd, J=8.1, 1.0 Hz, 1H), 7.65-7.55 (m, 3H), 7.47 (t, J=8.0 Hz, 1H), 4.48 (q, 1H, J=7.2 Hz), 3.25 (br s, 2H), 2.43-2.24 (m, 9H), 1.87 (d, J=14.2 Hz, 2H); MS (APCI) m/z 362 [M+H]+.

Aufarbeitung

  1. customThis compound was obtained in 25% yield as a white solid

Quellen und Nachweise

ORD-Eintrag
ord-7adac85e4c5c4b9495a7922956ed598d
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07781430B2

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