N-(3-ethynylphenyl)acetamide → HCID 11530439, Verbindung

HRID 506598Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 506598
[C:1](NC1C=C(C#C)C=CC=1)(=[O:3])C.[N+:13]([C:16]1[CH:17]=[C:18]2[CH:24]=[C:23]([C:25]3[CH:26]=[C:27]([NH:31][C:32](=[O:34])[CH3:33])[CH:28]=[CH:29][CH:30]=3)[NH:22][C:19]2=[N:20][CH:21]=1)([O-])=O.[CH3:35][C:36](C)([O-:38])[CH3:37].[K+]>>[CH:36]([O:38][C:1](=[O:3])[NH:13][C:16]1[CH:17]=[C:18]2[CH:24]=[C:23]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([NH:31][C:32](=[O:34])[CH3:33])[CH:26]=3)[NH:22][C:19]2=[N:20][CH:21]=1)([CH3:37])[CH3:35]

Komponenten

4

Edukt 3

HCID 2726447N-(3-ethynylphenyl)acetamideHCID 23665647Potassium tert-butoxideHCID 68462732N-[3-(5-Nitro-1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl]acetamide

Produkt 1

HCID 11530439HCID 11530439, Verbindung

Versuchsvorschrift

Was prepared analogously to example 9-2 starting from 3-(acetylamino)phenylacetylene. In the preparation of the intermediate N-[3-(5-nitro-1H-pyrrolo[2,3-b]pyridin-2-yl)-phenyl]-acetamide by cyclization reaction an higher equimolar amount of base (Potassium tert-butoxide) as in Example 2-2 is needed:

Quellen und Nachweise

ORD-Eintrag
ord-0774e8029cfd452db3d7f46a1be6b461
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786113B2

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