2,5-Dimethylpyrrolidine, (2R,5R)- → 8-(3-((2S,5S)-2,5-dimethylpyrrolidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one

HRID 506650

Reaktionsgleichung

Reaktionsgleichung von HRID 506650
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:19]=[CH:18][C:17]3[N:16]4[CH2:20][CH2:21][NH:22][C:23](=[O:24])[C:15]4=[CH:14][C:13]=3[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:25][C@H]1N[C@H](C)CC1>>[CH3:6][C@H:5]1[CH2:4][CH2:3][C@H:2]([CH3:25])[N:1]1[CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:19]=[CH:18][C:17]2[N:16]3[CH2:20][CH2:21][NH:22][C:23](=[O:24])[C:15]3=[CH:14][C:13]=2[CH:12]=1

Komponenten

3

Edukt 2

HCID 6417672,5-Dimethylpyrrolidine, (2R,5R)-HCID 166795198-(3-(piperidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one

Produkt 1

HCID 166796118-(3-((2S,5S)-2,5-dimethylpyrrolidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-oneAusbeute 7 %

Versuchsvorschrift

The title compound was synthesized in analogy to example 2, from 8-(3-chloro-propoxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 2, intermediate) and (2R,5R)-(−)-trans-2,5-dimethylpyrrolidine (commercially available), to give the desired product as a white solid (7%).

Quellen und Nachweise

ORD-Eintrag
ord-224bb1ff10e84f6188682ba4ecac6627
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786109B2

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