Sodium hydride → 9-Benzyloxy-2-cyclopropylmethyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

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Reaktionsgleichung

C(N1[CH2:9][CH2:8][CH:7]([O:10][C:11]2[CH:19]=[CH:18][C:17]3[N:16]4[CH2:20][CH2:21][CH2:22][NH:23][C:24](=[O:25])[C:15]4=[CH:14][C:13]=3[CH:12]=2)CC1)(C)C.Br[CH2:27][CH:28]1[CH2:30][CH2:29]1.[H-].[Na+]>>[CH2:7]([O:10][C:11]1[CH:19]=[CH:18][C:17]2[N:16]3[CH2:20][CH2:21][CH2:22][N:23]([CH2:27][CH:28]4[CH2:30][CH2:29]4)[C:24](=[O:25])[C:15]3=[CH:14][C:13]=2[CH:12]=1)[C:8]1[CH:9]=[CH:13][CH:12]=[CH:11][CH:19]=1

Komponenten

Edukt 3

HCID 24758Sodium hydride

HCID 81503Bromomethylcyclopropane

HCID 166797019-(1-Isopropyl-piperidin-4-yloxy)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one2×

Produkt 1

HCID 684657119-Benzyloxy-2-cyclopropylmethyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

Versuchsvorschrift

The title compound was synthesized in analogy to example 17, from 9-benzyloxy-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one (example 15, intermediate b)), 1-(bromomethyl)cyclopropane and sodium hydride, to give the compound as a white solid (76%).

Quellen und Nachweise

ORD-Eintrag: ord-489145aca8594353944d649bfaaf05a3
Quelldatensatz: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07786109B2

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