Hydrochloric Acid → N-Methyl-N-(piperidin-4-yl)acetamide

HRID 506858Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 506858
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:16](=[O:18])[CH3:17])[CH3:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCOC(C)=O>[CH3:15][N:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[C:16](=[O:18])[CH3:17]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22061331tert-Butyl 4-[acetyl(methyl)amino]piperidine-1-carboxylate

Produkt 1

HCID 21468403N-Methyl-N-(piperidin-4-yl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 4-(acetyl-methyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (525 mg, 2.05 mmol) in AcOEt (5 ml) was added HCl 3N (4 ml). The reaction mixture was stirred at RT for 16 hrs. Solvent were removed under reduced pressure to gine the expected N-methyl-N-piperidin-4-yl-acetamide as its hydrochloride salt (395 mg, quant.).

Aufarbeitung

  1. customSolvent were removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0dd63d0f2e3c4e5e9183e378ca92637d
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786121B2

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