1-(4-Fluoro-2-methylphenyl)piperazine → 3-Ethyl-3-{4-[4-(4-fluoro-2-methylphenyl)-piperazin-1-yl]-butyl}-1,3-dihydro-2H-indol-2-one monohydrochloride
Reaktionsgleichung
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1([CH2:16][CH3:17])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][C:7]1=[O:15].[F:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[C:21]([CH3:31])[CH:20]=1>>[ClH:1].[CH2:16]([C:6]1([CH2:5][CH2:4][CH2:3][CH2:2][N:28]2[CH2:27][CH2:26][N:25]([C:22]3[CH:23]=[CH:24][C:19]([F:18])=[CH:20][C:21]=3[CH3:31])[CH2:30][CH2:29]2)[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][C:7]1=[O:15])[CH3:17]Komponenten
3
Versuchsvorschrift
The title compound is prepared according to process H by applying processing method 2 from the starting compounds 3-(4-chlorobutyl)-3-ethyl-1,3-dihydro-2H-indol-2-one and 1-(4-fluoro-2-methylphenyl)-piperazine.
Quellen und Nachweise
- ORD-Eintrag
- ord-9e59816b89f1460196938fbc1034b476
- Quelldatensatz
- uspto-grants-2010_08