Triethylamine → HCID 60204465, Verbindung

HRID 507572

Reaktionsgleichung

Reaktionsgleichung von HRID 507572
Cl[C:2]1[N:7]=[C:6]([C:8]2[S:9][C:10]([I:13])=[CH:11][CH:12]=2)[CH:5]=[CH:4][N:3]=1.[NH2:14][CH2:15][CH2:16][N:17]1[C:21]([CH3:23])([CH3:22])[C:20](=[O:24])[NH:19][C:18]1=[O:25].C(N(CC)CC)C>CC(O)C>[I:13][C:10]1[S:9][C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:14][CH2:15][CH2:16][N:17]3[C:21]([CH3:22])([CH3:23])[C:20](=[O:24])[NH:19][C:18]3=[O:25])[N:7]=2)=[CH:12][CH:11]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 574288041-(2-Aminoethyl)-5,5-dimethylimidazolidine-2,4-dioneHCID 574288312-Chloro-4-(5-iodothiophen-2-yl)pyrimidine

Produkt 1

HCID 60204465HCID 60204465, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A solution of 205 mg (0.64 mmol) of 2-chloro-4-(5-iodothiophen-2-yl)pyrimidine, 186 mg (1.1 mmol) of 1-(2-aminoethyl)-5,5-dimethylimidazolidine-2,4-dione and 0.15 mL (1.1 mmol) of triethylamine in 5 mL of iPrOH was heated in a microwave to 180° C. for 10 min then concentrated in vacuo. The crude solid product was purified by flash chromatography eluting with a linear gradient of 40% EtOAc in hexane to 100% EtOAc to deliver the title compound. MS (M+H)+ 458.

Aufarbeitung

  1. concentrationthen concentrated in vacuo
  2. customThe crude solid product was purified by flash chromatography
  3. washeluting with a linear gradient of 40% EtOAc in hexane to 100% EtOAc

Quellen und Nachweise

ORD-Eintrag
ord-154e5e9e44dd42ff83076d4686cac6fa
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786132B2

Verknüpfte Notizen

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