Sodium Hydroxide → 7-Chloro-1-benzothiophene-2-carboxylic acid

HRID 507694Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 507694
[Cl:1][C:2]1[C:7]2[S:8][C:9]([C:11]([O:13]C)=[O:12])=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:7]2[S:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 22474203Methyl 7-chlorobenzo[b]thiophene-2-carboxylate

Produkt 1

HCID 101982427-Chloro-1-benzothiophene-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Methyl 7-chlorobenzo[b]thiophene-2-carboxylate (3 g, 13 mmol) was dissolved is ethanol (15 mL) and treated 5 N sodium hydroxide (5 mL). The reaction was heated at reflux overnight. The volatiles were removed in vacuo and the aqueous residue was acidified to pH 2 using 5 N HCl. The resulting white solid was filtered off, washed well with water and dried in a vacuum oven at 60° C. Yield=2.6 g. MS (M−H)− 210.

Aufarbeitung

  1. temperatureThe reaction was heated
  2. temperatureat reflux overnight
  3. customThe volatiles were removed in vacuo
  4. filtrationThe resulting white solid was filtered off
  5. washwashed well with water
  6. customdried in a vacuum oven at 60° C

Quellen und Nachweise

ORD-Eintrag
ord-fea189dc2932427e8c75b27d77b41223
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786132B2

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