Trifluoroacetic acid → 4-Aminonicotinic acid

HRID 50774

Reaktionsgleichung

Reaktionsgleichung von HRID 50774
C(OC([NH:8][C:9]1[C:14]([C:15]([OH:17])=[O:16])=[CH:13][N:12]=[CH:11][CH:10]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][C:9]1[C:14]([C:15]([OH:17])=[O:16])=[CH:13][N:12]=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 221726234-{[(Tert-butoxy)carbonyl]amino}pyridine-3-carboxylic acid

Produkt 1

HCID 3199794-Aminonicotinic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 4-(N-t-butoxycarbonylamino)nicotinic acid (2.72 g, 11.4 mmol), TFA (10 mL), and CH2Cl2 (20 mL) is stirred at room temperature for 12 h. The volatiles are removed under reduced pressure, and the resulting crude 4-amino nicotinic acid is used directly in the next reaction.

Aufarbeitung

  1. customThe volatiles are removed under reduced pressure
  2. customthe resulting crude 4-amino nicotinic acid is used directly in the next reaction

Quellen und Nachweise

ORD-Eintrag
ord-9e3cbd9745244c5e825a237891073967
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713484B2

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