2-Amino-5-chloropyridine → 3-(5-Chloropyrid-2-yl)carbamoylpyrazine-2-carboxylic acid

Beteiligte Stoffe

Reaktionsschritte

The addition of 2-amino-5-chloropyridine to pyrazine 2,3-dicarboxylic acid anhydride (II) in a lot wise manner at room temperature in a molar ratio of 1.05:1 surprisingly accelerates the reaction to completion in resulting the product, 3-(5-chloropyrid-2-yl)carbamoyl-pyrazine-2-carboxylic acid (III) having high purity (>99%) with a good yield of 85 to 90% when compared with the prior art processes.

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