Ethanol → 1,2-Diethoxy-3-fluorobenzene

HRID 507881

Reaktionsgleichung

Reaktionsgleichung von HRID 507881
[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:4]([OH:5])[C:3]=1[OH:9].[OH-].[Na+].[CH2:12](O)[CH3:13].Br[CH2:16][CH3:17]>ClCCl>[CH2:16]([O:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([F:1])[C:3]=1[O:9][CH2:12][CH3:13])[CH3:17]

Komponenten

6

Edukt 4

HCID 702Ethanol2×HCID 6332Ethyl BromideHCID 14798Sodium HydroxideHCID 677643-Fluorocatechol

Produkt 1

HCID 224601261,2-Diethoxy-3-fluorobenzeneAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

To a 500 ml flask were added 38.4 (0.3 mol) of 3-fluorocatechol [H], 12 g (0.3 mol) of sodium hydroxide and 100 ml of ethanol. After cooling to around 10° C., 100 ml of an ethanol solution of 76.3 g (0.7 mol) of bromoethane was slowly added. After the termination of the addition, they were reacted under a reflux temperature for 5 hours. After the termination of the reaction, dichloromethane was added, followed by extraction. The extraction liquid was washed with water and dried, and the solvent was removed by distillation to obtain 45.5 g of 1,2-diethoxy-3-fluorobenzene [G1] as an oily product. The process yield was 81%.

Aufarbeitung

  1. additionAfter the termination of the addition, they
  2. customwere reacted under a reflux temperature for 5 hours
  3. additionwas added
  4. extractionfollowed by extraction
  5. extractionThe extraction liquid
  6. washwas washed with water
  7. customdried
  8. customthe solvent was removed by distillation

Quellen und Nachweise

ORD-Eintrag
ord-d73a6277162945af817191edd1f34d31
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786330B2

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