Methylhydrazine → N-methyl-2-morpholinoacetohydrazide

HRID 508686

Reaktionsgleichung

Reaktionsgleichung von HRID 508686
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10]C)=O)[CH2:3][CH2:2]1.[CH3:12][NH:13][NH2:14]>C(O)C>[CH3:12][N:13]([C:8](=[O:10])[CH2:7][N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1)[NH2:14]

Komponenten

4

Edukt 2

HCID 6061MethylhydrazineHCID 1268178Methyl Morpholinoacetate

Produkt 1

HCID 86703007N-methyl-2-morpholinoacetohydrazideAusbeute 49,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

In a 25 mL, sealed tube, methyl 2-morpholinoacetate (0.5 g, 1.0 eq.) was dissolved in ethanol (5 mL) at RT. Methylhydrazine (0.16 g, 1.1 eq.) was introduced dropwise at RT and the reaction mixture was refluxed at 95° C. for 48 h. The reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg) to afford the crude N-methyl-2-morpholinoacetohydrazide (0.27 g) which was used without further purification in the following step.

Aufarbeitung

  1. customIn a 25 mL, sealed tube
  2. concentrationThe reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg)

Quellen und Nachweise

ORD-Eintrag
ord-b3474f529fd14022bccf6ff838c738a6
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096543B2

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