Sulfuric Acid → 2-Chloro-6-fluorobenzamide

HRID 508725

Reaktionsgleichung

Reaktionsgleichung von HRID 508725
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:12]>>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]([NH2:5])=[O:12]

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 695872-Chloro-6-fluorobenzonitrile

Produkt 1

HCID 985642-Chloro-6-fluorobenzamide

Versuchsvorschrift

A solution of 2-chloro-6-fluorobenzonitrile (8.0 g, 51.61 mmol) in conc. sulphuric acid (50 mL) was heated at 60-70° C. for 6-7 h. The reaction mass was quenched in water and extracted with DCM. The organic layer was dried over anhydrous sodium sulphate and concentrated to afford 5.5 g of desired product.

Aufarbeitung

  1. customThe reaction mass was quenched in water
  2. extractionextracted with DCM
  3. dry with materialThe organic layer was dried over anhydrous sodium sulphate
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-90a5ad7602f44967a9c0810810b17a30
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096545B2

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