Hydrochloric Acid → HCID 22736661, Verbindung

HRID 50890

Reaktionsgleichung

Reaktionsgleichung von HRID 50890
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH2:14].[F:15][C:16]([F:29])([F:28])[C:17]1[CH:18]=[C:19]([CH:25]=[CH:26][CH:27]=1)/[CH:20]=[CH:21]/[C:22]([Cl:24])=O.N1C=CC=CC=1N1C2C=CC=CC=2N=C1/C=C/C1C=CC=CC=1.Cl>CO>[ClH:24].[F:15][C:16]([F:28])([F:29])[C:17]1[CH:18]=[C:19]([CH:25]=[CH:26][CH:27]=1)/[CH:20]=[CH:21]/[C:22]1[N:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:14]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 752150N1-(pyridin-2-yl)benzene-1,2-diamineHCID 5375564trans-3-(Trifluoromethyl)cinnamoyl chlorideHCID 9796241(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

Produkt 1

HCID 22736661HCID 22736661, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and (E)-3-trifluoromethylcinnamoyl chloride (Amino, Y.; Kawada, K.; Toi, K.; Kumashiro, I.; Fukushima, K. Chem. Pharm. Bull., 1988, 36, 4426) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethanol yielded the titled compound. MW: 401.82; mp:>230° C.; 1H-NMR (DMSO) δ: 8.83-8.77 (1H, m), 8.14-8.06 (1H, m), 7.81(1H, d, J=7.7 Hz), 7.67 (1H, dd, J=7.3,4.8 Hz), 7.56-7.22 (10H, m).

Aufarbeitung

  1. concentrationConcentration and recrystallization from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-2d5c40e45c4342a885a813112182c3fc
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713482B2

Verknüpfte Notizen

Wird geladen…