Hydrochloric Acid → Methyl 2-(benzylamino)acetate hydrochloride

HRID 509183

Reaktionsgleichung

Reaktionsgleichung von HRID 509183
[CH2:1]([NH:8][CH2:9][C:10]([OH:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:13].[CH3:14]O>O1CCOCC1>[ClH:13].[CH2:1]([NH:8][CH2:9][C:10]([O:12][CH3:14])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 869652-(Benzylamino)acetic acid

Produkt 1

HCID 24192994Methyl 2-(benzylamino)acetate hydrochlorideAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a N-benzyl glycine 26 (500 mg, 3.0 mmol) in MeOH (6 mL) was added 4M solution of HCl in dioxane (4 mL) and stirred overnight. The reaction mixture was concentrated to afford compound 27 (649 mg, 99%) as a white solid. The crude compound was carried forward without further purification. LRMS (ESI): (calc) 179.2 (found) 180.1 (MH)+.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-38f9f87398bf4542975c2b2409b64c8e
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096565B2

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