HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → 5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 4-Methylphenylhydrazine monohydrochloride | HCID 12504 | — |
| Edukt | (2-Bromoethyl)cyclohexane | HCID 15440 | — |
| Edukt | 1-Methylpiperidin-4-one hydrochloride | HCID 12210057 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole | HCID 57876059 | 16,1% |
Reaktionsschritte
Preparation of the title compound was carried out according to General Method 8. p-Tolylhydrazine hydrochloride (500 mg, 3.1 mmol), 1-bromo-2-cyclohexylethane (602 mg, 3 mmol), triethyl amine (303 mg, 3 mmol) and N-methyl-4-piperidone hydrochloride (589 mg, 4.5 mmol) were combined in ethanol (3 ml) to obtain 150 mg of 5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole after purification on neutral alumina using ethyl acetate-hexane gradient.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09096591B2 |
| Quelldatensatz | uspto-grants-2015_08 |
| ORD ID | ord-931a9033a88b42589e0a518d836758ac |
| Quellennotiz | uspto-grants-2015_08 |