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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 509685Erstellt: 25. Oktober 2026

Triethylamine → 5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole

https://huagongshe.com/reaction/509685

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktTriethylamineHCID 8471—
Edukt4-Methylphenylhydrazine monohydrochlorideHCID 12504—
Edukt(2-Bromoethyl)cyclohexaneHCID 15440—
Edukt1-Methylpiperidin-4-one hydrochlorideHCID 12210057—
LösungsmittelEthanolHCID 702—
Produkt5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indoleHCID 5787605916,1%

Reaktionsschritte

Preparation of the title compound was carried out according to General Method 8. p-Tolylhydrazine hydrochloride (500 mg, 3.1 mmol), 1-bromo-2-cyclohexylethane (602 mg, 3 mmol), triethyl amine (303 mg, 3 mmol) and N-methyl-4-piperidone hydrochloride (589 mg, 4.5 mmol) were combined in ethanol (3 ml) to obtain 150 mg of 5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole after purification on neutral alumina using ethyl acetate-hexane gradient.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS09096591B2
Quelldatensatzuspto-grants-2015_08
ORD IDord-931a9033a88b42589e0a518d836758ac
Quellennotizuspto-grants-2015_08