Thionyl Chloride → 5-Fluoro-2-methoxy-nicotinoyl chloride

HRID 509999Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 509999
[F:1][C:2]1[CH:3]=[N:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:15])=O>>[F:1][C:2]1[CH:3]=[N:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([Cl:15])=[O:8]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 404270085-Fluoro-2-methoxynicotinic acid

Produkt 1

HCID 582594585-Fluoro-2-methoxy-nicotinoyl chloride

Versuchsvorschrift

In a round bottom flask, 5-fluoro-2-methoxy-nicotinic acid (150, 250 mg, 1.46 mmol) was combined with thionyl chloride (3.00 mL, 41.1 mmol) and the suspension was stirred at room temperature for 3 hours. The reaction was concentrated to dryness under vacuum to provide the desired compound, used in the next step without further purification.

Aufarbeitung

  1. concentrationThe reaction was concentrated to dryness under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b5896a84eebc46b49bf202c9bb13382c
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096593B2

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