Hydrochloric Acid → HCID 136364529, Verbindung

HRID 510053Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 510053
[Si]([O:8][C:9]1[C:10]([NH2:33])=[N:11][C:12]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[N:17]=2)=[N:13][C:14]=1[NH2:15])(C(C)(C)C)(C)C.Cl>O1CCCC1>[NH2:33][C:10]1[C:9]([OH:8])=[C:14]([NH2:15])[N:13]=[C:12]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[N:17]=2)[N:11]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 66614198HCID 66614198, Verbindung

Produkt 1

HCID 136364529HCID 136364529, VerbindungAusbeute 47,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

447 mg (0.96 mmol) of the compound obtained in example 57A were initially charged in 10 ml of tetrahydrofuran, and 6 ml of 3M hydrochloric acid were added. The next day, the mixture was concentrated to dryness and the residue was stirred with acetonitrile, water and dimethylformamide The precipitate was filtered off and washed with acetonitrile. 159 mg of the title compound were obtained (92% purity; 43% of theory).

Aufarbeitung

  1. concentrationThe next day, the mixture was concentrated to dryness
  2. filtrationwas filtered off
  3. washwashed with acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-2121db27b8f94743abe1dbe622b30754
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096592B2

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