(4-Methoxy-2-methylphenyl)boronic acid → HCID 21302661, Verbindung

HRID 51041Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 51041
Br[C:2]1[CH:3]=[C:4]2[C:8]3=[C:9]([S:11][CH2:12][CH2:13][N:7]3[C@H:6]3[CH2:14][CH2:15][N:16]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:17][C@@H:5]23)[CH:10]=1.[CH3:25][C:26]1[CH:31]=[C:30]([O:32][CH3:33])[CH:29]=[CH:28][C:27]=1B(O)O>>[CH3:33][O:32][C:30]1[CH:29]=[CH:28][C:27]([C:2]2[CH:3]=[C:4]3[C:8]4=[C:9]([S:11][CH2:12][CH2:13][N:7]4[C@H:6]4[CH2:14][CH2:15][N:16]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:17][C@@H:5]34)[CH:10]=2)=[C:26]([CH3:25])[CH:31]=1

Komponenten

3

Edukt 2

HCID 2773486(4-Methoxy-2-methylphenyl)boronic acidHCID 21302667tert-butyl(6bR,10aS)-5-bromo-1,2,6b,9,10,10a-hexahydropyrido[4,3-b][1,4]thiazino[2,3,4-hi]indole-8(7H)-carboxylate

Produkt 1

HCID 21302661HCID 21302661, VerbindungAusbeute 55 %

Versuchsvorschrift

The tert-butyl(6bR,10aS)-5-(4-methoxy-2-methylphenyl)-1,2,6b,9,10,10a-hexahydropyrido[4,3-b][1,4]thiazino[2,3,4-hi]indole-8(7H)-carboxylate (420 mg, 55%) was prepared via coupling of tert-butyl(6bR,10aS)-5-bromo-1,2,6b,9,10,10a-hexahydropyrido[4,3-b][1,4]thiazino[2,3,4-hi]indole-8(7H)-carboxylate (700 mg, 1.70 mmol) with 2-methyl-4-methoxyphenyl boronic acid (424 mg, 2.55 mmol) using the procedure described in Example 450 Step A.

Quellen und Nachweise

ORD-Eintrag
ord-f7f8f54b00af4f52b55c1773e07f6cb9
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713471B1

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