HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Formaldehyde → (2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Formaldehyde | HCID 712 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | (2S)-2-(4-methoxybenzylthiomethyl)pyrrolidine | HCID 57043207 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | (2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine | HCID 57048351 | 41,7% |
Reaktionsschritte
The procedure described in Preparation 5-(4) was repeated, but using 2 g of (2S)-2-(4-methoxybenzylthiomethyl)pyrrolidine, 35% formalin and 848 mg of sodium cyanoborohydride in the presence of 44 ml of acetonitrile, to afford 883 mg of the title compound as an oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05242914 |
| Quelldatensatz | uspto-grants-1993_09 |
| ORD ID | ord-1fc826cd6595419badb8308649438ba2 |
| Quellennotiz | uspto-grants-1993_09 |